GETTING MY PKRRATING TO WORK

The activated enzyme then phosphorylates its major substrate, the translational initiation element eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to your conserved spouse and children of 4 protein kinases (PKR, PERK, GCN2, HRI) that every one phosphorylate eIF2α in reaction to diverse stimuli12, triggering the built